CVE-2026-54604

Description

OpenSlide is a C library for reading whole slide image files. Prior to 4.0.1, a behavior change in libtiff 4.7.1 causes the indirect TIFF tile path in src/openslide-decode-tiff.c and _openslide_tiff_read_tile() to request a full-height destination for a partial bottom tile row, allowing uninitialized heap memory to enter pixel data returned by openslide_read_region(). A crafted but valid slide can trigger the issue in TIFF-based formats other than Hamamatsu NDPI when a network service renders attacker-provided slides. Successful extraction depends on pixel transparency handling and recompression, OpenSlide with libtiff 4.7.0 or earlier is not affected, and official binary builds 4.0.0.10 and 4.0.0.11 are affected. This issue is fixed in OpenSlide 4.0.1 and official binary build 4.0.0.12.

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Weakness Type (CWE)

CWE-758 CWE-758

CWE-908 CWE-908

References

Other References

https://github.com/openslide/openslide-bin/issues/433 https://github.com/openslide/openslide-bin/pull/436 https://github.com/openslide/openslide/commit/a4f0fb0ec462edcea97ff22288f606ac6cd370f5 https://github.com/openslide/openslide/pull/706 https://github.com/openslide/openslide/releases/tag/v4.0.1 https://github.com/openslide/openslide/security/advisories/GHSA-f734-jv98-5677 https://gitlab.com/libtiff/libtiff/-/work_items/791

Frequently Asked Questions

What is CVE-2026-54604? +

OpenSlide is a C library for reading whole slide image files. Prior to 4.0.1, a behavior change in libtiff 4.7.1 causes the indirect TIFF tile path in src/openslide-decode-tiff.c and _openslide_tiff_read_tile() to request a full-height destination for a partial bottom tile row, allowing uninitialized heap memory to enter pixel data returned by openslide_read_region(). A crafted but valid slide can trigger the issue in TIFF-based formats other than Hamamatsu NDPI when a network service renders attacker-provided slides. Successful extraction depends on pixel transparency handling and recompression, OpenSlide with libtiff 4.7.0 or earlier is not affected, and official binary builds 4.0.0.10 and 4.0.0.11 are affected. This issue is fixed in OpenSlide 4.0.1 and official binary build 4.0.0.12.

How do I check if I'm vulnerable to CVE-2026-54604? +

You can use Secably's free Website Scanner to check your website for known vulnerabilities. For infrastructure scanning, use the Port Scanner to identify exposed services that may be affected. Check the vendor advisories linked above for specific patch and version information.

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